Higher serum urate concentration is associated with decreased risk of Parkinson’s disease (PD) as well as slower disease progression, but its relationship with severity of PD remains unclear. This study investigated whether changes in serum urate concentration over 5 years were associated with disease progression assessed by MDS-UPDRS Part III score, Hoehn and Yahr stage, or DaTscan imaging. Average serum urate concentration was stable over time and change in serum urate concentration did not correlate with worsening of measures of PD progression. These results suggest that serum urate concentration is not a monitoring biomarker of PD progression in early stages.

中文翻译：

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血清尿酸会随着帕金森病的进展而变化吗？

较高的血清尿酸浓度与帕金森病 (PD) 风险降低以及疾病进展缓慢有关，但其与 PD 严重程度的关系尚不清楚。本研究调查了 5 年内血清尿酸浓度的变化是否与通过 MDS-UPDRS Part III 评分、Hoehn 和 Yahr 分期或 DaTscan 成像评估的疾病进展相关。平均血清尿酸浓度随时间稳定，血清尿酸浓度的变化与 PD 进展指标的恶化无关。这些结果表明，血清尿酸浓度不是早期 PD 进展的监测生物标志物。