Phytochemical investigation of extracts of the stems of Hypoestes aristata led to the isolation of nine lignans that included four known compounds, namely, hinokinin (1), savinin (2), medioresinol (3), and two cubebins (8a,b), three new butyrolactone lignans (4–6), and butyrolactol lignans 7a–c. The structures of the new compounds were established using 1D and 2D NMR and HRESIMS data. The absolute configurations of the new lignans were determined from their ECD data and the Mosher’s ester method. This is the first unequivocal assignment of the absolute configuration at C-7 and C-7′ of 7- and 7′-hydroxybutyrolactone lignans. The compounds were screened for inhibition of an HIV-1 protease enzyme, and compounds 1 and 6 exhibited moderate activity in this regard.

中文翻译：

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来自 Hypoestes aristata 的生物活性木脂素。

对Hypoestes aristata茎提取物的植物化学研究导致分离出九种木脂素，其中包括四种已知化合物，即桧木激肽 ( 1 )、savinin ( 2 )、medioresinol ( 3 ) 和两种立方体 ( 8a , b )、三种新的丁内酯木脂素 ( 4 – 6 ) 和丁内酯木脂素7a – c. 使用 1D 和 2D NMR 和 HRESIMS 数据确定了新化合物的结构。新木脂素的绝对构型由它们的 ECD 数据和 Mosher 酯方法确定。这是 7- 和 7'-羟基丁内酯木脂素的 C-7 和 C-7' 绝对构型的首次明确分配。筛选化合物对 HIV-1 蛋白酶的抑制作用，化合物1和6在这方面表现出中等活性。