当前位置: X-MOL 学术ACS Pharmacol. Transl. Sci. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
An Innovative in Vivo Model for Bioassay-Guided Testing of Potential Antimicrobials.
ACS Pharmacology & Translational Science Pub Date : 2020-08-03 , DOI: 10.1021/acsptsci.0c00091
Ruqaiyyah Siddiqui 1 , Naveed Ahmed Khan 1
Affiliation  

The use of in vivo models is critical in determining clinical relevance of potential chemotherapeutic molecules. Albeit mammals are of physiological relevance, the use of nonmammalian animals to investigate therapeutic efficacy of potential molecules at an initial stage of clinical research can complement in vitro studies. Here we suggest the use of a simple and inexpensive in vivo locust model in exploring the efficacy of novel chemotherapeutic molecules and/or large chemical libraries using high-throughput experimentation without legislative restrictions.

中文翻译:

一种创新的体内模型,用于潜在抗菌剂的生物测定引导测试。

体内模型的使用对于确定潜在化疗分子的临床相关性至关重要。尽管哺乳动物具有生理相关性,但在临床研究的初始阶段使用非哺乳动物来研究潜在分子的治疗功效可以补充体外研究。在这里,我们建议使用简单且廉价的体内蝗虫模型,在不受立法限制的情况下,使用高通量实验探索新型化疗分子和/或大型化学库的功效。
更新日期:2020-08-14
down
wechat
bug