Abstract Herein, we report the synthesis of substituted morpholino nucleoside derivatives starting from ribonucleosides. The present protocol shows high functional group tolerance, uses mild reaction conditions, and gives moderate to good yields. This transformation is based on two sequential pathways: (i) the oxidation of the ribonucleosides to the corresponding dialdehyde using sodium periodate and (ii) the reductive amination of the in situ generated dialdehydes with the hydrochloride salts of various the alkylamines.

中文翻译：

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N-取代吗啉核苷衍生物的合成

摘要在此，我们报道了从核糖核苷开始合成取代的吗啉代核苷衍生物。本协议显示出高官能团耐受性，使用温和的反应条件，并提供中等至良好的收率。这种转化基于两个连续途径：(i) 使用高碘酸钠将核糖核苷氧化成相应的二醛，以及 (ii) 原位生成的二醛与各种烷基胺的盐酸盐的还原胺化。