ABSTRACT

Past researches indicate that some types of antibiotics, apart from their antimicrobial effects, have some other important effects which indirectly are exerted by modulating and regulating the immune system’s mediators. Among the compounds with antimicrobial effects, fluoroquinolones (FQs) are known as synthetic antibiotics, which exhibit the property of decomposing of DNA and prevent bacterial growth by inactivating the enzymes involved in DNA twisting, including topoisomerase II (DNA gyrase) and IV. Interestingly, immune responses are indirectly modulated by FQs through suppressing pro-inflammatory cytokines, such as interleukin 1 (IL-1), IL-6, tumor necrosis factor-alpha (TNF-α), and super-inducing IL-2, which tend to increase both the growth and activity of T and B lymphocytes. In addition, they affect the development of immune responses by influencing of expression of other cytokines and mediators. This study aims to review past research on the immunomodulatory effects of FQs on the expression of cytokines, especially IL-2 and to discuss controversial investigations.

摘要

过去的研究表明，某些类型的抗生素除了具有抗菌作用外，还具有一些其他重要作用，这些作用是通过调节和调节免疫系统的介质间接发挥的。在具有抗菌作用的化合物中，氟喹诺酮类药物（FQs）被称为合成抗生素，它具有分解 DNA 的特性，通过使参与 DNA 扭曲的酶（包括拓扑异构酶 II（DNA 促旋酶）和 IV 失活）来防止细菌生长。有趣的是，免疫反应是由 FQ 通过抑制促炎细胞因子间接调节的，例如白细胞介素 1 (IL-1)、IL-6、肿瘤坏死因子-α (TNF-α) 和超诱导 IL-2，倾向于增加 T 和 B 淋巴细胞的生长和活性。此外，它们通过影响其他细胞因子和介质的表达来影响免疫反应的发展。本研究旨在回顾过去关于 FQs 对细胞因子，尤其是 IL-2 表达的免疫调节作用的研究，并讨论有争议的研究。