ABSTRACT The aim of this study was to evaluate the influence of Lactobacillus reuteri B1/1 on the local intestinal immune response in the cecum of chickens experimentally infected by C. jejuni CCM6189. Day-old chicken were divided into four groups: control (C), L. reuteri B1/1 (LR), C. jejuni CCM6189 (CJ), and combined L. reuteri B1/1 + C. jejuni CCM6189 (LRCJ). Cecal samples were collected during necropsy 12, 24, 48 hours after infection by C. jejuni (relative expression of NLRP3, caspase-1, interleukins, TLR4) and 4 as well as 7 day post infection (relative percentage of CD4+, CD8+, IgM). L. reuteri B1/1 significantly stimulated gene expression of NLRP3 inflammasome and other selected molecules, thereby increasing the capacity of the immune system to react more effectively to the infection of C. jejuni in chicken. In addition, an increase of IgM and the percentage of CD8+ influenced by L. reuteri was observed.

中文翻译：

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注射罗伊氏乳杆菌B1/1后感染空肠弯曲杆菌的肉鸡局部肠道免疫反应包括NLRP3炎性体

摘要 本研究的目的是评估罗伊氏乳杆菌 B1/1 对空肠弯曲杆菌 CCM6189 实验感染鸡盲肠局部肠道免疫反应的影响。日龄鸡分为四组：对照 (C)、罗伊氏乳杆菌 B1/1 (LR)、空肠弯曲杆菌 CCM6189 (CJ) 和罗伊氏乳杆菌 B1/1 + 空肠弯曲杆菌 CCM6189 (LRCJ) 组合。在空肠弯曲杆菌感染后 12、24、48 小时（NLRP3、caspase-1、白细胞介素、TLR4 的相对表达）和感染后 4 天和 7 天（CD4+、CD8+、IgM 的相对百分比）在尸检期间收集盲肠样本）。罗伊氏乳杆菌 B1/1 显着刺激了 NLRP3 炎症小体和其他选定分子的基因表达，从而提高了免疫系统对鸡中空肠弯曲杆菌感染更有效反应的能力。此外，