Herein is described the introduction of lipid moieties onto a simplified teixobactin pharmacophore using a modified Cysteine Lipidation on a Peptide or Amino acid (CLipPA) technique, whereby cysteine was substituted for 3-mercaptopropionic acid (3-MPA). A truncated teixobactin analog was prepared with the requisite thiol handle, thus enabling an array of vinyl esters to be conveniently conjugated onto the simplified teixobactin pharmacophore to yield S-lipidated cyclic lipopeptides.

中文翻译：

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硫醇使截短的S-脂化Teixobactin类似物的化学合成成为可能。

本文描述了使用在肽或氨基酸上的修饰的半胱氨酸脂化（CLipPA）技术将脂质部分引入简化的teixobactin药效团上，其中半胱氨酸代替3-巯基丙酸（3-MPA）。截短的teixobactin类似物具有必需的硫醇手柄，因此可以将一系列乙烯基酯方便地偶联到简化的teixobactin药效基团上，以产生小号脂化的环状脂肽。