当前位置: X-MOL 学术Front. Bioeng. Biotech. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Osteoporotic Goat Spine Implantation Study Using a Synthetic, Resorbable Ca/P/S-Based Bone Substitute
Frontiers in Bioengineering and Biotechnology ( IF 5.7 ) Pub Date : 2020-08-04 , DOI: 10.3389/fbioe.2020.00876
Bing-Chen Yang, Sheng-Min Lan, Chien-Ping Ju, Jiin-Huey Chern Lin

One primary purpose of the present study is to clarify whether the highly porous, resorbable Ca/P/S-based bone substitute used in this study would still induce an osteoporotic bone when implanted into the osteoporotic vertebral defects of ovariectomized (OVX) goats, or the newly-grown bone would expectantly be rather healthy bone. The bone substitute material used for the study is a synthetic, 100% inorganic, highly porous and fast-resorbable Ca/P/S-based material (Ezechbone® Granule CBS-400). The results show that the OVX procedure along with a low calcium diet and breeding away from light can successfully induce osteoporosis in the present female experimental goats. The histological examination reveals a newly-formed trabecular bone network within the surgically-created defect of the CBS-400-implanted (OVX_IP) goat. This new trabecular bone network in the OVX_IP goat appears much denser than the OVX goat and comparable to the healthy control goat. Histomorphometry show that, among all the experimental goats, the OVX_IP goat has the highest trabecular thickness and lowest trabecular bone packet prevalence. The differences in trabecular plate separation, trabecular number and trabecular bone tissue area ratio between the OVX_IP goat and the control goat are not significant, indicating that the trabecular bone architecture of the OVX_IP goat has substantially recovered to the normal level in about 6 months after implantation without signs of osteoporosis-related delay in the bone maturing process. The quick and nicely recovered trabecular architecture parameters observed in the OVX_IP goat indicate that the present Ca/P/S-based bone substitute material has a high potential to treat osteoporotic fractures.

中文翻译:

使用合成的、可吸收的 Ca/P/S 基骨替代物进行骨质疏松山羊脊柱植入研究

本研究的一个主要目的是阐明本研究中使用的高度多孔、可再吸收的基于 Ca/P/S 的骨替代品在植入去卵巢 (OVX) 山羊的骨质疏松性椎体缺损时是否仍会诱发骨质疏松症,或新长出的骨头应该是相当健康的骨头。用于研究的骨替代材料是一种合成的、100% 无机、高度多孔且可快速吸收的 Ca/P/S 基材料 (Ezechbone® Granule CBS-400)。结果表明,OVX 程序连同低钙饮食和避光饲养可以成功地诱导目前雌性实验山羊的骨质疏松症。组织学检查显示在 CBS-400 植入 (OVX_IP) 山羊的手术产生的缺陷内有一个新形成的骨小梁网络。OVX_IP 山羊中的这种新的小梁骨网络看起来比 OVX 山羊要密集得多,并且与健康对照山羊相当。组织形态测量显示,在所有实验山羊中,OVX_IP 山羊的骨小梁厚度最高,骨小梁包发生率最低。OVX_IP山羊与对照山羊在小梁板分离、小梁数量和小梁骨组织面积比方面的差异不显着,表明OVX_IP山羊的小梁骨结构在植入后约6个月内已基本恢复到正常水平在骨成熟过程中没有与骨质疏松症相关的延迟迹象。
更新日期:2020-08-04
down
wechat
bug