Lung cancer is one of the most common solid cancers and represents the leading cause of cancer death worldwide. Over the last decade, research on the epithelial-mesenchymal transition (EMT) in lung cancer has gained increasing attention. Here, we review clinical and histological features of non-small-cell lung cancer associated with EMT. We then aimed to establish potential clinical implications of EMT in current therapeutic options, including surgery, radiation, targeted therapy against oncogenic drivers, and immunotherapy.

中文翻译：

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肺癌上皮-间质转化作为辅助治疗决策的生物标志物的临床影响

肺癌是最常见的实体癌症之一，是全球癌症死亡的主要原因。在过去的十年中，关于肺癌上皮-间质转化（EMT）的研究越来越受到关注。在这里，我们回顾了与 EMT 相关的非小细胞肺癌的临床和组织学特征。然后，我们旨在确定 EMT 在当前治疗选择中的潜在临床意义，包括手术、放射、针对致癌驱动因素的靶向治疗和免疫治疗。