Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To date, there have been more than 10 million reported cases, more than 517,000 deaths in 215 countries, areas or territories. There is no effective antiviral medicine to prevent or treat COVID-19. Natural products and traditional medicine products with known safety profiles are a promising source for the discovery of new drug leads. There is increasing number of publications reporting the effect of natural products and traditional medicine products on COVID-19. In our review, we provide an overview of natural products and their derivatives or mimics, as well as traditional medicine products, which were reported to exhibit potential to inhibit SARS-CoV-2 infection in vitro, and to manage COVID-19 in vivo, or in clinical reports or trials. These natural products and traditional medicine products are categorized in several classes: (1) anti-malaria drugs including chloroquine and hydroxychloroquine, (2) antivirals including nucleoside analogs (remdesivir, favipiravir, β-D-N4-hydroxycytidine, ribavirin and among others), lopinavir/ritonavir and arbidol, (3) antibiotics including azithromycin, ivermectin and teicoplanin, (4) anti-protozoal drug, emetine, anti-cancer drug, homoharringtonine, and others, as well as (5) traditional medicine (Lian Hua Qing Wen Capsule, Shuang Huang Lian Oral Liquid, Qingfei Paidu Decoction and Scutellariae Radix). Randomized, double-blind and placebo-controlled large clinical trials are needed to provide solid evidence for the potential effective treatment. Currently, drug repurposing is a promising strategy to quickly find an effective treatment for COVID-19. In addition, carefully combined cocktails need to be examined for preventing a COVID-19 pandemic and the resulting global health concerns.

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天然产物衍生物和传统医学对COVID-19的意义

冠状病毒病2019（COVID-19）由严重的急性呼吸综合症冠状病毒2（SARS-CoV-2）引起。迄今为止，在215个国家，地区或地区已经有超过1000万例报告的病例，超过51.7万例死亡。没有有效的抗病毒药物来预防或治疗COVID-19。具有已知安全性的天然产品和传统药物产品是发现新药物线索的有前途的来源。越来越多的出版物报道了天然产物和传统药物对COVID-19的影响。在我们的评论中，我们概述了天然产物及其衍生物或模拟物，以及传统医药产品，据报道它们具有在体外抑制SARS-CoV-2感染并在体内管理COVID-19的潜力，或在临床报告或试验中。这些天然产品和传统药物产品分为几类：（1）抗疟疾药物，包括氯喹和羟基氯喹；（2）抗病毒药，包括核苷类似物（雷姆昔韦，favipiravir，β-D-N4-羟基胞苷，利巴韦林等） ，洛匹那韦/利托那韦和阿比多尔；（3）抗生素，包括阿奇霉素，伊维菌素和替考拉宁；（4）抗原生动物药物，速美汀，抗癌药，高灵敏素等，以及（5）传统药物（联华清温胶囊，双黄连口服液，清肺排毒汤，黄S。需要进行随机，双盲和安慰剂对照的大型临床试验，以为潜在的有效治疗提供可靠的证据。目前，重新调整药物用途是快速找到有效的COVID-19治疗方法的有前途的策略。此外，还需要对精心组合的鸡尾酒进行检查，以防止COVID-19大流行和由此引起的全球健康问题。