Two new diterpenoid derivatives 7α,12β,17-triacetoxy-6β,19-dihydroxy-13β,16-spirocicloabiet-8-ene-11,14-dione (1: ) and 6β-acetoxy-3β,7α,12α-trihydroxy-13β,16-spirocicloabiet-8-ene-11,14-dione (2: ) along with 11 (3: -13: ) miscellaneous compounds were isolated from the leaves of Plectranthus ornatus Codd. Their structures were elucidated by spectroscopic analysis and gauge independent atomic orbitals 13C NMR calculations. The isolated compounds were screened for their effects on intestinal motility using guinea-pig ileum and duodenum and by their cytotoxicity against 4 human cancer cell lines (HCT-116, SF-295, PC-3, and HL-60). Compounds 6: and 9: were moderately cytotoxic against HL-60, whereas 6: and 13: were more active on SF-295 and HCT-116.

中文翻译：

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来自栽培的 Plectranthus ornatus 叶子的二萜类化合物

两种新的二萜衍生物 7α,12β,17-triacetoxy-6β,19-dihydroxy-13β,16-spirocicloabiet-8-ene-11,14-dione (1: ) 和 6β-acetoxy-3β,7α,12α-trihydroxy-从 Plectranthus ornatus Codd 的叶子中分离出 13β,16-spirocicloabiet-8-ene-11,14-dione (2: ) 以及 11 (3: -13: ) 杂项化合物。它们的结构通过光谱分析和规范独立的原子轨道 13C NMR 计算得到阐明。使用豚鼠回肠和十二指肠筛选分离的化合物对肠道运动的影响，以及它们对 4 种人类癌细胞系（HCT-116、SF-295、PC-3 和 HL-60）的细胞毒性。化合物 6: 和 9: 对 HL-60 有中等的细胞毒性，而 6: 和 13: 对 SF-295 和 HCT-116 的活性更高。