To prepare a thin film, the block copolymer poly(TMCM‐MOE3OM)‐b‐PTMC was prepared with different segment ratios of hydrophilic moiety. The glass transition temperature of poly(TMCM‐MOE3OM)‐b‐PTMC decreased as the content of TMCM‐MOE3OM increased as expected, and it was confirmed that the graft oligo(ethylene glycol) (OEG) affected intermolecular interaction. The polymers grafted with OEG showed a thermoresponsive property, which can be expected to be applied to materials triggered by temperature. A thin film was prepared by mixing block copolymer and cilostazol as a drug, and the distribution of cilostazol was observed. It was confirmed that cilostazol was uniformly distributed on the thin film and that local sustained release could be avoided at the time of elution. The eluting behavior of the thin film from the substrate was apparently affected on the segment ratio of the block copolymer. When the thin film was immersed in PBS, the eluting rate increased as the segment ratio of TMCM‐MOE3OM in the block copolymer increased. As a result, it is possible to control the eluting rate by changing the ratio of the hydrophilicity and the hydrophobicity of the block copolymer, contributing to the creation of a new coating material containing cilostazol.

中文翻译：

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含碳酸亚丙酯的低聚乙二醇酯合成两亲嵌段共聚物及西洛他唑薄膜的研究

为了制备薄膜，制备了嵌段共聚物聚（TMCM-MOE3OM）-b -PTMC ，其亲水性部分的链段比例不同。聚（TMCM‐MOE3OM）‐ b的玻璃化转变温度‐PTMC随TMCM‐MOE3OM含量的增加而降低，并证实了接枝寡聚乙二醇（OEG）影响了分子间的相互作用。用OEG接枝的聚合物表现出热响应特性，可以预期将其应用于温度触发的材料。通过将嵌段共聚物和西洛他唑作为药物混合来制备薄膜，并观察到西洛他唑的分布。证实西洛他唑均匀地分布在薄膜上，并且在洗脱时可以避免局部持续释放。薄膜从基材上的洗脱行为显然受到嵌段共聚物的链段比的影响。当将薄膜浸入PBS中时，随着嵌段共聚物中TMCM-MOE3OM链段比例的增加，洗脱速率增加。