The peri‐implantation period is controlled by signals originating from hypothalamic–pituitary–ovarian axis, uterus and developing embryos. The transcriptomic activity of the anterior pituitary gland may be important for the control of the peri‐implantation period. The aim of this study was to determine the alternations in the transcriptomic profile of porcine anterior pituitary gland during the peri‐implantation period (days 15–16 of pregnancy) in comparison with established for the respective days of the oestrous cycle. Analysis using a microarray approach indicated that the 651 genes (fold‐change ˂1.2; p ≤ .05) were differentially expressed (DEGs) in the anterior pituitary of pigs during the peri‐implantation period when compared to cyclic females. Of these DEGs, 404 were upregulated and 247 downregulated. Analysis of occurred relationships among DEGs revealed that some of them are involved in steroid‐response and oestrogen synthesis, FSH secretion, immune response, PPAR signalling pathway and the potential for DNA methylation. In conclusion, the altered transcriptomic profile of the porcine pituitary gland in pigs during the peri‐implantation period indicates the role of embryos presence in the creation of transcriptomic activity of the pituitary gland in pigs.

中文翻译：

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围着床期猪垂体前叶的转录组学分析。

围着床期由来自下丘脑-垂体-卵巢轴、子宫和发育中的胚胎的信号控制。垂体前叶的转录活性可能对控制着床期很重要。本研究的目的是确定围着床期（妊娠第 15-16 天）猪垂体前叶的转录组变化与发情周期各天的变化比较。使用微阵列方法的分析表明，651 个基因（倍数变化 ˂1.2；p ≤ .05) 在围植入期猪的垂体前叶中差异表达 (DEG) 与周期性雌性相比。在这些 DEG 中，404 个被上调，247 个被下调。对DEGs之间发生关系的分析表明，其中一些涉及类固醇反应和雌激素合成、FSH分泌、免疫反应、PPAR信号通路和DNA甲基化的潜力。总之，在胚胎着床期间，猪脑垂体的转录组学特征发生了改变，这表明胚胎的存在在猪脑垂体转录组活动的产生中发挥了作用。