Acrylamide (ACR) is produced during food processing and has been shown to cause health problems. Selenium, especially in its nanoscale, is an important trace element in human nutrition. Chitosan‐stabilized selenium nanoparticles (Ch‐SeNPs) stability and its protective potential against ACR‐induced injury in rats were evaluated. Ch‐SeNPs displayed high radical‐scavenging activity and reducing power that were not significantly changed for 60 days at 4°C. The transmission electron microscopy images and dynamic light scattering results demonstrated high stability of Ch‐SeNPs during storage. ACR (20 mg kg⁻¹ day⁻¹) led to elevate the level of malondialdehyde, dopamine and noradrenaline in blood serum, and cerebral cortex. Ch‐SeNPs (0.2 mg kg⁻¹ day⁻¹) displayed more protection against ACR‐induced damages comparing to Na₂SeO₃. More than 90% of the glutathione pool in the brain tissue was in reduced form. Correlation coefficient analysis demonstrated the attenuating effect of Ch‐SeNPs against ACR‐induced brain‐injury and hormone imbalance. Administrating Ch‐SeNPs 15 days before ACR‐treatment is required for obtaining the best protection.

中文翻译：

---

壳聚糖稳定的硒纳米颗粒可减轻丙烯酰胺诱导的大鼠脑损伤。

丙烯酰胺（ACR）是在食品加工过程中产生的，已被证明会引起健康问题。硒，尤其是其纳米级的硒，是人体营养中的重要微量元素。评估了壳聚糖稳定的硒纳米颗粒（Ch-SeNPs）的稳定性及其对大鼠ACR损伤的保护潜力。Ch-SeNPs具有较高的自由基清除活性和还原能力，在4°C下60天未发生明显变化。透射电子显微镜图像和动态光散射结果表明，Ch-SeNPs在存储过程中具有很高的稳定性。ACR（20毫克千克^-1 天^-1）导致提升丙二醛，多巴胺和血清中的去甲肾上腺素，和大脑皮层的水平。Ch-SeNPs（0.2 mg kg ^-1 天^-1）与Na ₂ SeO ₃相比，对ACR诱导的损伤显示出更多的保护作用。脑组织中超过90％的谷胱甘肽池处于还原状态。相关系数分析表明，Ch-SeNPs对ACR引起的脑损伤和激素失衡具有减弱作用。为了获得最佳保护，需要在ACR治疗前15天管理Ch-SeNP。