Dyssodia decipiens is one of the seven recognized species within the Dyssodia genus, which has economic and social relevance in Mexico. Herein, we report on the volatile characterization and pharmacological activity of D. decipiens. The essential oils (2017–2019) contained verbenone (30.8–60.9 %), limonene (5.6–35.5 %), β‐caryophyllene (7.8–19.8 %) and linalool (4.5–12.4 %) as major constituents along the studied years. Antifungal properties were probed on Candida albicans ATCC 90028, ATCC 10231 (fluconazole resistant) and five clinical isolates (IS1–IS5). Flower essential oils had the best anti‐C. albicans activity (MIC 59.2–93.5 μg mL−1), and limonene (MIC 125.5–188.4 μg mL−1) and β‐caryophyllene (MIC 104.3–184.2 μg mL−1) were involved in this effect. SEM examination revealed that D. decipiens essential oils produced an evident lysis on the fungus. Mosquito repellent activity was demonstrated on Aedes aegypti, a vector of dengue, chikungunya and zika viruses. The repellent activity of leaf essential oils (20 %) was effective within 1–5 h post‐treatment (>90 %) and it was stronger (p<0.01) than that of commercial DEET. The evaluation of the four major volatiles (10 % each) produced similar results to those of essential oils. Finally, leaf essential oils showed a moderate antiproliferative activity on the lines OVCAR‐3 (LD50 56.5–85.7 μg mL−1), and verbenone (LD50 65.3 μg mL−1) and β‐caryophyllene (LD50 43.6 μg mL−1) were linked to this effect.

中文翻译：

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Dyssodia decipiens 精油的化学变异和药理特性

Dyssodia decipiens 是 Dyssodia 属中七种公认的物种之一，在墨西哥具有经济和社会意义。在此，我们报告了 D. decipiens 的挥发性特征和药理活性。精油（2017-2019）包含马鞭草酮（30.8-60.9%）、柠檬烯（5.6-35.5%）、β-石竹烯（7.8-19.8%）和芳樟醇（4.5-12.4%）作为研究年份的主要成分。对白色念珠菌 ATCC 90028、ATCC 10231（氟康唑耐药）和五个临床分离株（IS1-IS5）的抗真菌特性进行了探测。花精油具有最好的抗 C。白色念珠菌的活性 (MIC 59.2–93.5 μg mL-1)、柠檬烯 (MIC 125.5–188.4 μg mL-1) 和 β-石竹烯 (MIC 104.3–184.2 μg mL-1) 与此作用有关。SEM 检查显示 D. decipiens 精油对真菌产生明显的裂解作用。在埃及伊蚊（登革热、基孔肯雅热和寨卡病毒的载体）上证明了驱蚊活性。叶精油 (20%) 的驱避活性在处理后 1-5 小时内有效 (>90%)，并且比商业避蚊胺的驱蚊活性更强 (p<0.01)。四种主要挥发物（各 10%）的评估产生了与精油相似的结果。最后，叶精油对 OVCAR-3 (LD50 56.5–85.7 μg mL-1)、马鞭草酮 (LD50 65.3 μg mL-1) 和 β-石竹烯 (LD50 43.6 μg mL-1) 系显示出中等的抗增殖活性与这种效果有关。叶精油 (20%) 的驱避活性在处理后 1-5 小时内有效 (>90%)，并且比商业避蚊胺的驱蚊活性更强 (p<0.01)。四种主要挥发物（各 10%）的评估产生了与精油相似的结果。最后，叶精油对 OVCAR-3 (LD50 56.5–85.7 μg mL-1)、马鞭草酮 (LD50 65.3 μg mL-1) 和 β-石竹烯 (LD50 43.6 μg mL-1) 系显示出中等的抗增殖活性与这种效果有关。叶精油 (20%) 的驱避活性在处理后 1-5 小时内有效 (>90%)，并且比商业避蚊胺的驱蚊活性更强 (p<0.01)。四种主要挥发物（各 10%）的评估产生了与精油相似的结果。最后，叶精油对 OVCAR-3 (LD50 56.5–85.7 μg mL-1)、马鞭草酮 (LD50 65.3 μg mL-1) 和 β-石竹烯 (LD50 43.6 μg mL-1) 系显示出中等的抗增殖活性与这种效果有关。