Erythroleukemia disease is caused by over production of malignant blood and immature large number of blood cells enters into peripheral compartment. Biophysical and biochemical changes in plasma and erythrocyte membrane in erythroleukemia treated rats were identified. Our study, leukemia is experimentally exposed in rats were injecting erythroleukemia cells (FLC) (H-2d) intravenously in adult rats and normal control rats were maintained. Significant increase in the activity of blood glucose, proteins levels, aspartate transaminase (AST) and alanine transaminase (ALT) values and significant decrease in haemoglobin (Hb), albumin levels in erythroleukemia treated rats were observed when compared with control rats. Cholesterol and low density liproprotein (LDL) levels increased significantly in erythroleukemia treated rats but triglycerides, high density lipoprotein (HDL) and very low density lipoprotein (VLDL) levels decreased significantly. Levels of red cell membrane cholesterol decreased in erythroleukemia treated rats in comparison with control while levels of phospholipids and proteins increased in erythrocytes of erythroleukemia treated rats. Red blood cell (RBC) and white blood cell (WBC) counts increased significantly and platelet count decreased. C/P (cholesterol/phospholipid) ratio decreased significantly in erythroleukemia treated rats. This study has been undertaken for the first time to investigate the effect of (FLC) (H-2d) erythroleukemia cells (treated) in intravenously in adult rats and normal control rats. Results indicate biophysical and biochemical alterations at molecular level in plasma and erythrocyte membrane.

红血球疾病是由恶性血液过多产生引起的，未成熟的大量血细胞进入外周腔室。鉴定了在红白血病患者中血浆和红细胞膜的生物物理和生化变化。我们的研究中，白血病是通过实验暴露于大鼠中，并通过静脉注射成年大鼠和正常对照大鼠的红白血病细胞（FLC）（H-2d）。与对照组相比，红细胞白血病大鼠的血糖，蛋白水平，天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）值显着增加，血红蛋白（Hb），白蛋白水平显着下降。在红白血病治疗的大鼠中，胆固醇和低密度脂蛋白（LDL）的水平显着增加，但甘油三酸酯，高密度脂蛋白（HDL）和极低密度脂蛋白（VLDL）的水平明显降低。与对照组相比，红细胞白血病大鼠的红细胞膜胆固醇水平降低，而红细胞白血病大鼠的红细胞膜磷脂和蛋白质水平升高。红细胞（RBC）和白细胞（WBC）计数显着增加，血小板计数减少。在红白血病治疗的大鼠中，C / P（胆固醇/磷脂）比率显着降低。这项研究是首次进行，以研究（FLC）（H-2d）红白血病细胞（经治疗）在成年大鼠和正常对照大鼠中的静脉内作用。结果表明血浆和红细胞膜在分子水平上的生物物理和生化改变。