Bioavailability is an important concept when evaluating natural products for their bioactivities. The present study measured the bioavailability of phenolics of Sambucus ebulus (dwarfelder) fruit extracts, along with its antioxidant activity after simulated digestion. Total phenolics, phenolic acid, proanthocyanidin and flavonoid content assays were used along with different antioxidant assays such as metal reducing and free radical scavenging activities. High performance thin layer chromatography was used to measure bioactive metabolite of the plant sample, chlorogenic acid. Results indicated that aqueous and methanolic extracts of S. ebulus fruits were affected by simulated human digestion, alterations in antioxidant activity were consistent with the changes in the phenolics. Chlorogenic acid bioavailability rates were calculated as 45.8 and 51.9% for methanolic and aqueous extracts, respectively. Total antioxidant capacity was reduced to 37 ± 0.5 from 82 ± 4 (AAE)/g DE for methanolic extracts after the digestion process.

当评估天然产物的生物活性时，生物利用度是一个重要的概念。本研究测量了接骨木（dwarfelder）果实提取物中酚类的生物利用度，以及模拟消化后其抗氧化活性。总酚，酚酸，原花青素和类黄酮含量测定与不同的抗氧化剂测定（如金属还原和自由基清除活性）一起使用。高效薄层色谱法用于测量植物样品绿原酸的生物活性代谢物。结果表明，水和甲醇提取出的红景天水果受到模拟人体消化的影响，抗氧化活性的变化与酚类物质的变化一致。甲醇提取物和水性提取物的绿原酸生物利用度分别计算为45.8％和51.9％。消化过程后，甲醇提取物的总抗氧化剂容量从82±4（AAE）/克DE降低到37±0.5。