We describe a novel strategy to increase the unit-time-productivity of flow synthesis by using hierarchical bimodal porous silica gel (HBPSG) supported palladium column reactors. Because HBPSG has a significantly large surface area, the column reactors have low pressure drop, enabling high-volume production. We demonstrated flow synthesis of the precursor of adapalene, a pharmaceutical compound, at 5 g/h which is over 10-fold greater productivity than previous approaches.

中文翻译：

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通过具有低压降的分级双峰多孔硅胶负载钯柱反应器实现的每小时流量生产

我们描述了一种通过使用分层双峰多孔硅胶 (HBPSG) 支持的钯柱反应器来提高流动合成的单位时间生产率的新策略。由于 HBPSG 具有显着大的表面积，因此塔式反应器的压降较低，可实现大批量生产。我们展示了阿达帕林前体（一种药物化合物）的流动合成，速度为 5 g/h，其生产率比以前的方法高 10 倍以上。