Allergic diseases have been a global problem over the past few decades. The effect of allergic diseases on healthcare systems and society is generally remarkable and is considered as one of the most common causes of chronic and hospitalized disease. The functional ability of probiotics to modulate the innate/acquired immune system leads to the initiation of mucosal/systemic immune responses. Gut microbiota plays a beneficial role in food digestion, development of the immune system, control/growth of the intestinal epithelial cells and their differentiation. Prescribing probiotics causes a significant change in the intestinal microflora and modulates cytokine secretion, including networks of genes, TLRs, signaling molecules and increased intestinal IgA responses. The modulation of the Th1/Th2 balance is done by probiotics, which suppress Th2 responses with shifts to Th1 and thereby prevent allergies. In general, probiotics are associated with a decrease in inflammation by increasing butyrate production and induction of tolerance with an increase in the ratio of cytokines such as IL-4, IL-10/IFN-γ, Treg/TGF-β, reducing serum eosinophil levels and the expression of metalloproteinase-9 which contribute to the improvement of the allergic disease’s symptoms. Finally, it can be said that the therapeutic approach to immunotherapy and the reduction of the risk of side effects in the treatment of allergic diseases is the first priority of treatment and the final approach that completes the first priority in maintaining the condition and sustainability of the tolerance along with the recovery of the individual

在过去的几十年里，过敏性疾病一直是一个全球性的问题。过敏性疾病对医疗保健系统和社会的影响普遍显着，被认为是慢性病和住院疾病的最常见原因之一。益生菌调节先天/后天免疫系统的功能能力导致粘膜/全身免疫反应的启动。肠道微生物群在食物消化、免疫系统发育、肠上皮细胞的控制/生长及其分化方面发挥着有益的作用。服用益生菌会导致肠道菌群发生显着变化并调节细胞因子分泌，包括基因网络、TLR、信号分子和肠道 IgA 反应增加。Th1/Th2 平衡的调节是由益生菌完成的，从而抑制 Th2 反应并转变为 Th1，从而防止过敏。一般来说，益生菌通过增加丁酸盐的产生和诱导耐受性，增加细胞因子（如 IL-4、IL-10/IFN-γ、Treg/TGF-β）的比例，降低血清嗜酸性粒细胞，从而减少炎症水平和金属蛋白酶 9 的表达有助于改善过敏性疾病的症状。最后，可以说免疫疗法的治疗方法和降低过敏性疾病治疗中副作用的风险是治疗的第一要务，也是完成第一要务的最终方法，以维持患者的病情和可持续性。随着个体恢复的耐受性 益生菌通过增加丁酸盐的产生和诱导耐受性，增加细胞因子（如 IL-4、IL-10/IFN-γ、Treg/TGF-β）的比例，降低血清嗜酸性粒细胞水平和金属蛋白酶9的表达有助于改善过敏性疾病的症状。最后，可以说免疫疗法的治疗方法和降低过敏性疾病治疗中副作用的风险是治疗的第一要务，也是完成第一要务的最终方法，以维持过敏性疾病的状态和可持续性。随着个体恢复的耐受性 益生菌通过增加丁酸盐的产生和诱导耐受性，增加细胞因子（如 IL-4、IL-10/IFN-γ、Treg/TGF-β）的比例，降低血清嗜酸性粒细胞水平和金属蛋白酶9的表达有助于改善过敏性疾病的症状。最后，可以说免疫疗法的治疗方法和降低过敏性疾病治疗中副作用的风险是治疗的第一要务，也是完成第一要务的最终方法，以维持过敏性疾病的状态和可持续性。随着个体恢复的耐受性