Calcium aluminum phosphate cement (CAPC) requires a practical composition for biological applications. This research aims to investigate the effect of aluminum hydroxide sources (aluminum hydroxide, boehmite, and hydratable alumina), where SECAR 71 cement and phosphoric acid are in the composition, regarding the mechanical, biological, and microstructural properties of CAPC. In vitro assessments were evaluated by immersing the samples in simulated body fluid (SBF) solution for 7 days, 14 days, and 28 days, and by MTT testing (cytotoxicity of MG-63 cells). The results revealed that the composition including hydratable alumina was superior concerning the lowest final setting time (50 min), in situ formation and growth of hydroxyapatite on its surface, as well as the compressive strength which reaches to 42 ± 10 MPa after 28 days in SBF solution. However, regarding the cytotoxicity, the cements consisting of boehmite have priority. A more detailed biological analysis is recommended to evaluate the clinical application of CAPC.

中文翻译：

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用于潜在生物应用的磷酸铝钙水泥的相和微观结构演变：氢氧化铝源的影响

磷酸铝钙水泥 (CAPC) 需要用于生物应用的实用组合物。本研究旨在研究氢氧化铝源（氢氧化铝、勃姆石和可水合氧化铝）对 CAPC 机械、生物和微观结构特性的影响，其中 SECAR 71 水泥和磷酸在组合物中。通过将样品浸入模拟体液 (SBF) 溶液中 7 天、14 天和 28 天，并通过 MTT 测试（MG-63 细胞的细胞毒性）来评估体外评估。结果表明，包含可水合氧化铝的组合物在最低最终凝固时间（50 分钟）、羟基磷灰石在其表面的原位形成和生长以及在 28 天后达到 42±10 MPa 的抗压强度方面均优异。 SBF 解决方案。然而，关于细胞毒性，由勃姆石组成的水泥具有优先权。建议进行更详细的生物学分析来评估 CAPC 的临床应用。