To compare structural features of the femoral bone of ovariectomized and non-ovariectomized rats after implantation of porous materials (TANTALUM, CONCELOC, TTM, ATLANT). Experiments were carried out on 56 white laboratory female rats aged 6 months. Rats were randomly assigned into groups: sham-operated control group (SH) or ovariectomy group (OVX). Four different commercial implant materials (TTM, CONCELOC, TANTALUM, ATLANT) were placed into the defects (diameter 2.5 mm, depth 3.0 mm) in the distal metaphysis of femurs. Rats were sacrificed 45 days after surgery. Histological study was performed and the percentage of the bone area (BA%) around the implant at a distance of 500 μm in the cancellous area was measured. Formation of mature bone tissue of varying degrees around all of the implants was detected. In OVX rats cancellous bone defect zone was characterized by a high density of osteocytes on the surface. In the SH group, no differences in BA% among implant materials were found. In OVX rats, the BA% around ATLANT implants was 1.5-time less (p = 0.002) than around TANTALUM. The BA% around the rest of the materials was not statistically different. Bone formation around the studied porous titanium and tantalum materials in the osteoporosis model was lower than in normal bone. There were differences in bone formation around the different materials in the osteoporosis model, while in the normal bone model, these differences were absent.

中文翻译：

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评价卵巢切除大鼠股骨远端放置的四种类型的多孔金属植入物周围的骨形态。

为了比较植入多孔材料（TANTALUM，CONCELOC，TTM，ATLANT）后去卵巢和未去卵巢大鼠股骨的结构特征。实验对56个6个月大的白色实验雌性大鼠进行。将大鼠随机分为两组：假手术对照组（SH）或卵巢切除组（OVX）。将四种不同的商用植入物材料（TTM，CONCELOC，TANTALUM，ATLANT）放入股骨远端干physi端的缺损处（直径2.5 mm，深度3.0 mm）。手术后45天处死大鼠。进行组织学研究，并测量松质区域中距离500μm的植入物周围的骨面积百分比（BA％）。在所有植入物周围检测到不同程度的成熟骨组织形成。在OVX大鼠中，松质骨缺损区的特征是表面上的骨细胞密度高。在SH组中，植入物材料之间的BA％没有差异。在OVX大鼠中，ATLANT植入物周围的BA％比TANTALUM周围的BA％小1.5倍（p = 0.002）。其余材料的BA％在统计上没有差异。在骨质疏松症模型中，研究的多孔钛和钽材料周围的骨形成低于正常骨。在骨质疏松症模型中，不同材料周围的骨形成存在差异，而在正常骨模型中，则没有这些差异。002）。其余材料的BA％在统计上没有差异。在骨质疏松症模型中，研究的多孔钛和钽材料周围的骨形成低于正常骨。在骨质疏松症模型中，不同材料周围的骨形成存在差异，而在正常骨模型中，则没有这些差异。002）。其余材料的BA％在统计上没有差异。在骨质疏松症模型中，研究的多孔钛和钽材料周围的骨形成低于正常骨。在骨质疏松症模型中，不同材料周围的骨形成存在差异，而在正常骨模型中，则没有这些差异。