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Simple Synthesis of Amides via Their Acid Chlorides in Aqueous TPGS-750-M
Organic Process Research & Development ( IF 3.4 ) Pub Date : 2020-08-03 , DOI: 10.1021/acs.oprd.0c00303
Min Shi 1 , Ning Ye 1 , Wei Chen 1 , Hui Wang 1 , Chiming Cheung 1 , Michael Parmentier 2 , Fabrice Gallou 2 , Bin Wu 1
Affiliation  

The technology of surfactant chemistry is employed for amide bond construction via the reaction of acyl chlorides with amines in 2 wt % TPGS-750-M aqueous solution. Specifically, this highly efficient method enables a chromatography-free scalable process and recycling of the TPGS-750-M solution.

中文翻译:

在TPGS-750-M水溶液中通过酰氯简单地合成酰胺

通过酰基氯与胺在2 wt%TPGS-750-M水溶液中的反应,将表面活性剂化学技术用于酰胺键的构建。特别是,这种高效的方法可以实现无色谱的可扩展过程,并可以回收TPGS-750-M解决方案。
更新日期:2020-08-21
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