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Effect of Preoperative Zoledronic Acid Administration on Pain Intensity after Percutaneous Vertebroplasty for Osteoporotic Vertebral Compression Fractures.
Pain Research and Management ( IF 2.9 ) Pub Date : 2020-08-03 , DOI: 10.1155/2020/8039671
Weiran Hu 1, 2 , Hongqiang Wang 1, 2 , Xinge Shi 1, 2 , Yuepeng Song 1, 2 , Guangquan Zhang 1, 2 , Shuai Xing 1, 2 , Kai Zhang 1, 2 , Yanzheng Gao 1, 2
Affiliation  

Introduction. This study aimed to compare and analyze the effect of preoperative zoledronic acid (ZOL) administration on pain intensity after percutaneous vertebroplasty (PVP) for osteoporotic vertebral compression fracture (OVCF). Methods. The study included 242 patients with OVCFs who underwent PVP in our hospital between January 2015 and June 2018. The patients were randomly assigned to either a ZOL group (n = 121) or a control group (n = 121). The patients in the ZOL group were treated preoperatively with intravenous infusion of 5 mg ZOL. Those in the control group were treated without ZOL. All the patients were followed up for 1 year. Results. No statistically significant differences in age, sex, weight, and body mass index (BMI) were found between the two groups. During the follow-up period, the visual analog scale score and Oswestry dysfunction index score in the ZOL group were lower than those in the control group. The bone mineral density at 6 or 12 months after treatment was significantly higher and the levels of the bone metabolism markers were significantly lower in the ZOL group than in the control group ( for both). Two patients in the treatment group had new vertebral fractures, whereas 13 patients in the control group had new vertebral fractures, which translate to recompression vertebral fracture incidence rates of 1.7% and 10.7%, respectively. The incidence rate of mild adverse reactions was significantly higher in the ZOL group than in the control group, but all the cases were endurable. Conclusion. Intravenous infusion of ZOL before PVP can effectively reduce postoperative pain intensity, reduce bone loss, increase bone density, reduce the risk of refracture, and improve patient quality of life.

中文翻译:

术前给予唑来膦酸对骨质疏松性椎体压缩性骨折经皮椎体成形术后疼痛强度的影响。

介绍。这项研究旨在比较和分析术前唑来膦酸(ZOL)给药对骨质疏松性椎体压缩性骨折(OVCF)的经皮椎体成形术(PVP)后疼痛强度的影响。方法。该研究纳入了2015年1月至2018年6月在我院接受PVP的242例OVCF患者。这些患者被随机分为ZOL组(n  = 121)或对照组(n  = 121)。ZOL组的患者在术前接受了5 mg ZOL的静脉输注。对照组的患者未接受ZOL治疗。所有患者均获随访1年。结果。两组之间在年龄,性别,体重和体重指数(BMI)上均没有统计学上的显着差异。在随访期间,ZOL组的视觉模拟量表评分和Oswestry功能障碍指数评分均低于对照组。与对照组相比,ZOL组在治疗后6或12个月的骨矿物质密度显着更高,并且骨代谢标志物的水平显着降低(对彼此而言)。治疗组中有2例患者有新的椎体骨折,而对照组中有13例患者有新的椎体骨折,这意味着再压缩椎体骨折的发生率分别为1.7%和10.7%。ZOL组轻度不良反应的发生率显着高于对照组,但所有病例均可以耐受。结论。PVP之前静脉输注ZOL可有效降低术后疼痛强度,减少骨质流失,增加骨密度,降低再次手术的风险并改善患者的生活质量。
更新日期:2020-08-03
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