Background. This retrospective study aims at comparing the variation of peripheral inflammatory markers in recurrent and cancerous vocal fold leukoplakia (VFL) and at exploring the potential connection with pathological outcomes. Methods. The patients undergoing carbon dioxide laser surgery with postoperative pathological diagnosis of recurrent vocal fold leukoplakia in the last 5 years were included. The clinical data were collected, and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocytes-to-lymphocyte ratio (MLR) before and after recurrence and canceration were calculated. Related comparison with two-grade pathological classification was made to evaluate their potential connection with postsurgical histopathology and clinical events. Results. The data of 193 patients were engaged into research, as 111 in the recurrence group (Group A) and 82 in canceration group (Group B). The NLR, PLR, and MLR were significantly increased in canceration event compared to the first (, respectively) and penultimate (, respectively) time when the previous pathologies were leukoplakia. When redividing the Group A according to the two-grade pathological classification, the high-risk groups showed statistically higher NLR and PLR values than low-risk groups in the subgroups with grade changing (, respectively) and subgroups without grade changing (, respectively). Conclusions. NLR, PLR, and MLR are reliable biomarkers in the circulation system which show significantly interrelation with the pathological progression of vocal fold leukoplakia. Presurgical evaluation of NLR, PLR, and MLR may have potential values to indicate the following treatment in clinical practice.

中文翻译：

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复发癌变前后声带白斑外周炎症标志物的变化。

背景。这项回顾性研究旨在比较复发性和癌性声带白斑（VFL）中外周炎症标志物的变化，并探索与病理结果的潜在联系。方法。纳入近5年接受二氧化碳激光手术且术后病理诊断为复发性声带白斑的患者。收集临床资料，计算复发癌变前后的中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、单核细胞与淋巴细胞比值（MLR）。与二级病理分类进行相关比较，以评估其与术后组织病理学和临床事件的潜在联系。结果. 共纳入193例患者的资料，其中复发组（A组）111例，癌变组（B组）82例。与第一次相比，癌变事件中的 NLR、PLR 和 MLR 显着增加（，分别）和倒数第二个（，分别）以前的病理是白斑的时间。将A组按照2级病理分类重新划分时，在分级变化的亚组中，高危组的NLR和PLR值显着高于低危组（，分别）和没有等级变化的子组（，分别）。结论。NLR、PLR和MLR是循环系统中可靠的生物标志物，与声带白斑的病理进展有显着的相互关系。NLR、PLR 和 MLR 的术前评估可能具有指示临床实践中以下治疗的潜在价值。