Genomes are highly organized in space and time. Compartments, topologically associating domains (TADs) and loops are three dimensional (3D) genome features that have been extensively studied. Among these three levels of organization, TADs have sparked the most debate. New microscopy data shed light on how TADs and their leaky borders contribute to gene regulation.

中文翻译：

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TAD无国界。

基因组在空间和时间上高度组织。隔室，拓扑关联域（TAD）和环是已被广泛研究的三维（3D）基因组特征。在这三个组织级别中，TAD引发了最多的辩论。新的显微镜数据揭示了TAD及其泄漏边界如何促进基因调控。