Abstract

The study of oxidation kinetics of drug molecules is of much noteworthy in order to understand their mechanistic chemistry in redox systems. Taurine, being a potent drug molecule, has a wide range of activities in biological system. Therefore, the kinetics of oxidation of taurine (TAU) by bromamine-T (BAT) in HCl medium, catalyzed by Ru(III) and in NaOH medium, catalyzed by Os(VIII) has been investigated at 313 K. The rate law in acidic medium is: rate = k[BAT]_t[TAU]⁰[Ru(III)]^0.95[H⁺]^−0.67. But, it takes the form, rate = k[BAT]_t[TAU]^0.46[Os(VIII)]^0.89[OH⁻]^−0.53 in basic medium. Addition of halide ions and p-toluenesulfonamide had no significant effect on the rate in both the cases. Decrease in dielectric constant of medium decreases the reaction rate in both the media. The conjugate acid, CH₃C₆H₄SO₂NHBr (TsNHBr), is assumed to be the oxidizing species in both the media. Equilibrium and decomposition constants have been evaluated in each case.

抽象的

为了了解它们在氧化还原系统中的机理化学，对药物分子的氧化动力学的研究非常值得关注。牛磺酸是一种有效的药物分子，在生物系统中具有广泛的活性。因此，已经研究了在313 K下由Ru（III）催化的HCl介质和Os（VIII）催化的NaOH介质中的溴胺T（BAT）氧化牛磺酸（TAU）的动力学。酸性介质为：速率＝ k [BAT] _t [TAU] ⁰ [Ru（III）] ^0.95 [H ⁺ ] ^-0.67。但是，它需要的形式，速率= K [BAT]_吨[TAU] ^0.46 [锇（VIII）] ^0.89 [OH ^- ] ^-0.53在基本介质中。在这两种情况下，添加卤离子和对甲苯磺酰胺均对速率没有显着影响。介质介电常数的降低会降低两种介质的反应速率。共轭酸CH ₃ C ₆ H ₄ SO ₂ NHBr（TsNHBr）被认为是两种介质中的氧化性物质。在每种情况下均已评估了平衡常数和分解常数。