Abstract

Two new transition coordination polymers (CPs) with the chemical formula of {[Zn₄(dip)₄(H₂O)₂(4-ppbp)₂]·12H₂O}_n (1, H₂dpa = diphenic acid, 4-ppbp = (propane-1,3-diylbis(piperazine-4,1-diyl))bis(pyridin-4-ylmethanone)) and [Co(dipH)₂(bdin)]_n (2, bdin = N,N-(butane-1,3-diyl)diisonicotinamide) have been successfully prepared by reaction of the corresponding metal salts with the H₂dpa ligand in the presence of different flexible dipyridylamide ligands. Its treatment activity combined with epidural anesthesia for hip replacement was evaluated. First, the hip replacement operation was carried on experimental mice, followed by the compound given combined with epidural anesthesia. The animal survival rate as well as the rate of anesthesia was recorded and analyzed. In addition to this, the blood pressure level of the mice was also determined throughout the procession of the hip replacement operation.

抽象的

化学式为{[Zn ₄（dip）₄（H ₂ O）₂（4-ppbp）₂ ] · 12H ₂ O} _n（1，H ₂ dpa = diphenic acid， 4-ppbp =（丙烷-1,3-二基双（哌嗪-4,1-二基））双（吡啶-4-基甲酮））和[Co（dipH）₂（bdin）] _n（2，bdin = N，通过相应的金属盐与H _2的反应已成功制备了N-（丁烷-1,3-二基）二异烟酰胺（N-（butane-1,3-diyl）diisonicotinamide）在不同的柔性二吡啶酰胺配体存在下的dpa配体。评价了其治疗活性与硬膜外麻醉联合进行髋关节置换的效果。首先，对实验小鼠进行髋关节置换手术，然后将所给的化合物与硬膜外麻醉相结合。记录并分析动物的存活率以及麻醉率。除此之外，在髋关节置换手术的整个过程中还确定了小鼠的血压水平。