ABSTRACT

Background

Measuring the health-related quality of life is an essential estimation in cost–utility studies. In this research, we provide new evidence about comparing utility scores – in the field of substance dependence. Although the main objective is to compare the EQ-5D-5L and SF-6D with paired gamble, evidence about the SF-6D with standard gamble is also provided.

Methods

Ninety-four patients with substance dependence were recruited; the SF-6D and the EQ-5D-5L were administered at the beginning of treatment and 6 months thereafter. Differences in treatment effect were estimated by comparing utility gains. All analyses were reproduced for two subgroups of severity.

Results

Both the baseline scores and the treatment effect are sensitive to the instrument used. For severe states, the SF-6D with paired gamble (SF-6D with standard gamble) estimates the lowest (highest) utility. With regard to the impact of treatment, the EQ-5D-5L and SF-6D with paired gamble estimate strongly similar effects for severe states (and both estimate greater effects than does the SF-6D with standard gamble).

Conclusions

These findings have implications for cost–utility analyses. The incremental cost-utility ratio of treatments intended for severe states is barely sensitive to the choice of EQ-5D-5L or SF-6D with paired gamble.

中文翻译：

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测量因物质依赖接受治疗的患者的健康相关生活质量：引发偏好的工具和方法之间的差异

摘要

背景

衡量与健康相关的生活质量是成本效用研究中必不可少的估计。在这项研究中，我们提供了关于比较效用得分的新证据——在物质依赖领域。虽然主要目标是将 EQ-5D-5L 和 SF-6D 与配对赌博进行比较，但也提供了有关 SF-6D 与标准赌博的证据。

方法

招募了 94 名物质依赖患者；SF-6D 和 EQ-5D-5L 在治疗开始时和之后 6 个月给药。通过比较效用增益来估计治疗效果的差异。所有分析都针对两个严重程度亚组进行了复制。

结果

基线分数和治疗效果都对使用的仪器很敏感。对于严重状态，带有配对赌博的 SF-6D（带有标准赌博的 SF-6D）估计最低（最高）效用。关于治疗的影响，带有配对赌博的 EQ-5D-5L 和 SF-6D 估计对严重状态的影响非常相似（并且两者都估计出比带有标准赌博的 SF-6D 更大的影响）。

结论

这些发现对成本效用分析有影响。用于严重状态的治疗的增量成本效用比对选择 EQ-5D-5L 或 SF-6D 与配对赌博几乎不敏感。