Abstract

Three new neoflavonoids, named (1S,8R,9S)-1,5-dihydroxy-4,12-dimethoxy-8-vinyl-tricyclo[7.3.1.0^2,7]trideca-2,4,6,11-tetraen-10-one (1), 2,5,2',5'-tetrahydroxy-4-methoxybenzophenone (2) and 2,5,3'-trihydroxy-4-methoxybenzophenone (3), were isolated from the heartwood of Dalbergia melanoxylon. Their structures were established by spectroscopic methods, including UV, IR, HRMS, 1 D and 2 D-NMR. Compounds 1-3 were evaluated for inhibitory activity against three fungal strains Candida albicans, Mucor ramosissimus, Saccharomycopsis fermentans and seven bacterial strains Shigella dysenteriae, Salmonella enteri, Bacillus cereus, Staphylococcus epidermidis, Bacillus sphaericus, Staphylococcus aureus, Escherichia coli using the broth dilution method. However, none of compounds 1–3 showed potential antimicrobial activities in vitro.

摘要

三种新类黄酮，命名为 (1S,8R,9S ) -1,5 - dihydroxy-4,12-dimethoxy-8-vinyltricyclo[7.3.1.0 2,7 ] ^trideca -2,4,6,11 -tetraen-10-一（1），2,5,2',5'-四羟基-4-甲氧基二苯甲酮（2）和2,5,3'-三羟基-4-甲氧基二苯甲酮（3 ），是从黄檀的心材中分离得到的。它们的结构是通过光谱方法建立的，包括紫外、红外、HRMS、一维和二维核磁共振。评估了化合物1 - 3对三种真菌菌株白色念珠菌、分枝毛霉、发酵酵母菌和7株痢疾杆菌、肠沙门氏菌、蜡状芽孢杆菌、表皮葡萄球菌、球形芽孢杆菌、金黄色葡萄球菌、大肠杆菌采用肉汤稀释法。然而，化合物1-3均未在体外显示出潜在的抗菌活性。