ABSTRACT

Immune responses play an important role in the fate of bladder cancer tumors. Treg cells are immunosuppressive and down-regulate the proliferation of effector T cells, which favor tumor survival. Ghrelin is a hormone that stimulates release of growth hormone and anti-inflammatory response to cancer cells. Ghrelin also is a gastrointestinal hormone that regulates immune responses via the growth hormone secretagogue receptor (GHS-R1a). The relation among ghrelin, its receptor, and Treg cells that surround bladder tumors is not clear. We found that Foxp3⁺ T and GHS-R1a cells are increased significantly in bladder tumor tissues. Therefore, we suggest that ghrelin may increase the number of Treg cells in the tumor and suppress activity of the immune system against bladder cancer.

摘要

免疫反应在膀胱癌肿瘤的命运中起着重要作用。Treg 细胞具有免疫抑制作用并下调效应 T 细胞的增殖，这有利于肿瘤存活。生长激素释放肽是一种刺激生长激素释放和对癌细胞的抗炎反应的激素。生长激素释放肽也是一种胃肠激素，通过生长激素促分泌素受体 (GHS-R1a) 调节免疫反应。ghrelin、其受体和膀胱肿瘤周围的 Treg 细胞之间的关系尚不清楚。我们发现膀胱肿瘤组织中 Foxp3 ⁺ T 和 GHS-R1a 细胞显着增加。因此，我们认为ghrelin可能会增加肿瘤中Treg细胞的数量并抑制免疫系统对膀胱癌的活性。