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Effects of Ramadan Intermittent Fasting on Gut Hormones and Body Composition in Males with Obesity.
International Journal of Environmental Research and Public Health ( IF 4.614 ) Pub Date : 2020-08-03 , DOI: 10.3390/ijerph17155600
Hassane Zouhal 1 , Reza Bagheri 2 , Raoua Triki 3 , Ayoub Saeidi 4 , Alexei Wong 5 , Anthony C Hackney 6 , Ismail Laher 7 , Katsuhiko Suzuki 8 , Abderraouf Ben Abderrahman 3
Affiliation  

We studied the effects of Ramadan intermittent fasting (RIF) on gut hormones (leptin, glucagon-like peptide-1 (GLP-1), peptide YY (PYY), cholecystokinin (CCK), and ghrelin) in males with obesity. Thirty sedentary males were randomly allocated to either an experimental group (EG, n = 15) or a control group (CG, n = 15). The EG group completed their Ramadan fasting rituals (30 days), whereas the CG continued with their normal daily habits. Blood samples were collected at four time points: 24 h before the start of Ramadan (T0), on the 15th day of Ramadan (T1), the day after the end of Ramadan (T2) and 21 days after Ramadan (T3). There were significant pre-to-post improvements for leptin (p = 0.01, d = 1.52), GLP-1 (p = 0.022, d = 0.75), PYY (p = 0.031, d = 0.69) and CCK (p = 0.027, d = 0.81) in the EG, with no interaction effect for ghrelin (p = 0.74; d = 0.008). No significant changes (p > 0.05) occurred in plasma volume variations (ΔPV) after RIF in both EG (−0.03 ± 0.01%) and CG (0.06 ± 0.07%). RIF represents an effective strategy to modify appetite-regulating hormones, leading to improved body composition indices and reduced obesity.

中文翻译:

斋月间歇性禁食对肥胖男性肠道激素和身体成分的影响。

我们研究了斋月间歇性禁食 (RIF) 对肥胖男性肠道激素(瘦素、胰高血糖素样肽-1 (GLP-1)、肽 YY (PYY)、胆囊收缩素 (CCK) 和生长素释放肽)的影响。30 名久坐不动的男性被随机分配到实验组(EG,n = 15)或对照组(CG,n = 15)。EG 组完成了他们的斋月禁食仪式(30 天),而 CG 组则继续他们的正常日常习惯。在四个时间点采集血样:斋月开始前 24 小时(T0)、斋月第 15 天(T1)、斋月结束后的第二天(T2)和斋月后 21 天(T3)。瘦素 ( p = 0.01, d = 1.52)、GLP-1 ( p= 0.022, d = 0.75), PYY ( p = 0.031, d = 0.69) 和 CCK ( p = 0.027, d = 0.81) 在 EG 中,对 ghrelin 没有交互作用 ( p = 0.74; d = 0.008)。RIF 后 EG (-0.03 ± 0.01%) 和 CG (0.06 ± 0.07%) 的血浆体积变化 (ΔPV)没有显着变化 ( p > 0.05)。RIF 代表了一种改变食欲调节激素的有效策略,从而改善身体成分指数并减少肥胖。
更新日期:2020-08-03
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