A fast and reliable synthesis of pyrazole-substituted iodolium triflates is described. Their versatile application as useful synthetic intermediates for straight-forward modifications of pharmaceuticals is demonstrated using Celecoxib as model substrate. Finally, their application as potent halogen-bond donors in a Ritter-type reaction is shown.


中文翻译：

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碘吡唑鎓盐–合成，衍生化和应用

描述了吡唑取代的碘鎓三氟甲磺酸酯的快速和可靠的合成。使用塞来昔布作为模型底物，证明了它们作为有用的合成中间体进行药物直接修饰的用途广泛。最后，显示了它们在Ritter型反应中作为有效的卤素键供体的应用。