Glucagon-like peptide 1 infusions overcome anabolic resistance to feeding in older human muscle.,Aging Cell

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Glucagon-like peptide 1 infusions overcome anabolic resistance to feeding in older human muscle.
Aging Cell ( IF 7.8 ) Pub Date : 2020-08-03 , DOI: 10.1111/acel.13202
Haitham Abdulla _{1,

2} , Bethan E Phillips _{1,

3} , Daniel J Wilkinson ₁ , Marie Limb ₁ , Tereza Jandova ₁ , Joseph J Bass ₁ , Debbie Rankin ₁ , Jessica Cegielski ₁ , Mariwan Sayda ₁ , Hannah Crossland ₁ , John P Williams _{1,

4} , Kenneth Smith _{1,

3} , Iskandar Idris _{1,

3,

5} , Philip J Atherton _{1,

3}

Affiliation

Despite its known insulin‐independent effects, glucagon‐like peptide‐1 (GLP‐1) role in muscle protein turnover has not been explored under fed‐state conditions or in the context of older age, when declines in insulin sensitivity and protein anabolism, as well as losses of muscle mass and function, occur.

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