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Porpholactone Chemistry: Shining New Light on an Old Cofactor.
ChemPlusChem ( IF 3.4 ) Pub Date : 2020-08-02 , DOI: 10.1002/cplu.202000494
Guo-Qing Jin 1 , Hao-Zong Xue 1 , Jun-Long Zhang 1
Affiliation  

The emergence of porpholactone chemistry, discovered over 30 years ago, has significantly stimulated the development of biomimetic tetrapyrrole chemistry. It offers an opportunity, through modifications of non‐pyrrolic building blocks, to clarify the relationship between chemical structure and excited‐state properties, deciphering the structural code for the biological functions of life pigments. With intriguing photophysical properties in the red to near‐infrared (NIR) regions, facile modulation of their electronic nature by fine‐tuning chemical structures, and coordination ability with diverse metal ions, these novel porphyrinoids have favorable prospects in the fields of optical materials, bioimaging and therapy, and catalysis. In this Minireview, we summarize the brief history of porpholactone chemistry, and focus on the studies carried out in our group, particularly on the regioisomeric effect, NIR lanthanide luminescence, and metal catalysis. We outline the perspectives of these compounds in the construction of porpholactone‐related biomedical applications and optical and energy materials, in order to inspire more interest and further advance bioinspired inorganic chemistry and lanthanide chemical biology.

中文翻译:

卟啉内酯化学:在旧的辅助因子上发光。

三十多年前发现的卟啉内酯化学的出现极大地刺激了仿生四吡咯化学的发展。通过修改非吡咯基的结构单元,它提供了一个机会来阐明化学结构与激发态性质之间的关系,从而破译了生命颜料的生物学功能的结构代码。这些新颖的卟啉类化合物在红色到近红外(NIR)区域具有令人着迷的光物理特性,可以通过微调化学结构轻松调节其电子性质,并与多种金属离子具有配位能力,因此在光学材料领域具有良好的前景,生物成像和治疗以及催化作用。在此Minireview中,我们总结了卟啉内酯化学的简要历史,并专注于我们小组中进行的研究,尤其是区域异构效应,NIR镧系元素发光和金属催化。我们概述了这些化合物在与卟啉内酯相关的生物医学应用以及光学和能量材料的构建中的观点,以激发更多的兴趣并进一步推动受生物启发的无机化学和镧系元素化学生物学。
更新日期:2020-08-02
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