Alterations in adult hypothalamic–pituitary–adrenal (HPA) axis activity have increasingly been linked with early life stress and adult depression, but a limited number of studies have used longitudinal data to explore HPA axis dysregulation as an underlying mechanism driving the long‐term depressive impacts of early stressors. Here we address potential long‐term impacts of early life, family‐based stress on depressive symptoms among young adults in a longitudinal birth cohort study begun in 1983 in the Philippines.

中文翻译：

---

早期生活压力和 HPA 轴功能独立预测菲律宾宿务大都市的成人抑郁症状。

成人下丘脑-垂体-肾上腺 (HPA) 轴活动的改变越来越多地与早期生活压力和成人抑郁症联系起来，但有限数量的研究使用纵向数据来探索 HPA 轴失调作为驱动长期抑郁症的潜在机制早期应激源的影响。在这里，我们在 1983 年在菲律宾开始的一项纵向出生队列研究中探讨了早期生活、基于家庭的压力对年轻人抑郁症状的潜在长期影响。