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Metal‐Specific Biomaterial Accumulation in Human Peri‐Implant Bone and Bone Marrow
Advanced Science ( IF 15.1 ) Pub Date : 2020-08-03 , DOI: 10.1002/advs.202000412
Janosch Schoon 1, 2, 3 , Bernhard Hesse 4, 5 , Anastasia Rakow 2, 6 , Melanie J Ort 1, 2, 3 , Adrien Lagrange 4, 7 , Dorit Jacobi 1, 2 , Annika Winter 8 , Katrin Huesker 9 , Simon Reinke 1, 2 , Marine Cotte 5, 10 , Remi Tucoulou 5 , Uwe Marx 8 , Carsten Perka 2, 3, 6 , Georg N Duda 1, 2, 3 , Sven Geissler 1, 2, 3
Affiliation  

Metallic implants are frequently used in medicine to support and replace degenerated tissues. Implant loosening due to particle exposure remains a major cause for revision arthroplasty. The exact role of metal debris in sterile peri‐implant inflammation is controversial, as it remains unclear whether and how metals chemically alter and potentially accumulate behind an insulating peri‐implant membrane, in the adjacent bone and bone marrow (BM). An intensively focused and bright synchrotron X‐ray beam allows for spatially resolving the multi‐elemental composition of peri‐implant tissues from patients undergoing revision surgery. In peri‐implant BM, particulate cobalt (Co) is exclusively co‐localized with chromium (Cr), non‐particulate Cr accumulates in the BM matrix. Particles consisting of Co and Cr contain less Co than bulk alloy, which indicates a pronounced dissolution capacity. Particulate titanium (Ti) is abundant in the BM and analyzed Ti nanoparticles predominantly consist of titanium dioxide in the anatase crystal phase. Co and Cr but not Ti integrate into peri‐implant bone trabeculae. The characteristic of Cr to accumulate in the intertrabecular matrix and trabecular bone is reproducible in a human 3D in vitro model. This study illustrates the importance of updating the view on long‐term consequences of biomaterial usage and reveals toxicokinetics within highly sensitive organs.

中文翻译:

人类种植体周围骨和骨髓中金属特异性生物材料的积累

金属植入物在医学上经常用于支持和替换退化的组织。由于颗粒暴露导致的植入物松动仍然是修正关节置换术的主要原因。金属碎片在无菌种植体周围炎症中的确切作用存在争议,因为目前尚不清楚金属是否以及如何发生化学变化并可能在邻近的骨和骨髓(BM)中的种植体周围绝缘膜后面积聚。集中聚焦且明亮的同步加速器 X 射线束可以在空间上解析接受修复手术的患者种植体周围组织的多元素组成。在种植体周围 BM 中,颗粒状钴 (Co) 专门与铬 (Cr) 共定位,非颗粒状 Cr 积聚在 BM 基质中。由 Co 和 Cr 组成的颗粒含有比合金块更少的 Co,这表明具有显着的溶解能力。BM 中含有丰富的颗粒钛 (Ti),分析的钛纳米颗粒主要由锐钛矿晶相的二氧化钛组成。Co 和 Cr 但不整合到种植体周围骨小梁中。Cr 在小梁间基质和骨小梁中积累的特性在人体 3D 体外模型中是可重现的。这项研究说明了更新对生物材料使用的长期后果的看法的重要性,并揭示了高度敏感器官内的毒代动力学。
更新日期:2020-08-03
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