High quality of sleep may mitigate the impact of pathophysiological mechanisms in mild cognitive impairment (MCI) through functional connectivity reorganization of neural networks underlying higher cognitive functions. Thirty-eight patients with MCI stratified into high and low quality of sleep in accordance with a self-reported questionnaire for sleep habits, and 38 controls underwent resting-state functional magnetic resonance imaging. Independent component analysis was used to reconstruct the default mode network and frontoparietal network (FPN). High quality of sleep was associated with increased FPN connectivity among patients with MCI. Moreover, a positive coupling of connectivity between networks was found in MCI reporting high quality of sleep, congruently with the pattern observed in controls, whereas this coupling was disrupted in MCI with low quality of sleep. An association between FPN connectivity and language scores was observed in MCI. These findings suggest a relationship between sleep quality and FPN connectivity in MCI that may underlie compensatory mechanisms to overcome advancing neurodegeneration.

中文翻译：

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睡眠质量可预测轻度认知障碍患者的额顶网络连通性增加

高质量的睡眠可以通过更高认知功能基础的神经网络的功能连接重组来减轻病理生理机制对轻度认知障碍 (MCI) 的影响。根据睡眠习惯的自我报告问卷，38 名 MCI 患者分为高睡眠质量和低睡眠质量，38 名对照组接受静息状态功能磁共振成像。独立成分分析用于重建默认模式网络和额顶网络（FPN）。高质量睡眠与 MCI 患者的 FPN 连接增加有关。此外，在报告高质量睡眠的 MCI 中发现了网络之间连接的正耦合，与对照组中观察到的模式一致，而这种耦合在睡眠质量低的 MCI 中被破坏。在 MCI 中观察到 FPN 连接和语言分数之间的关联。这些发现表明 MCI 中睡眠质量和 FPN 连接之间的关系，这可能是克服推进神经退行性疾病的补偿机制的基础。