Rice bran is a by-product of rice milling, which contains variety of nutrients, and has been reported to possess various activities. Here, we used high fat (HF) diet induced mice to investigate the effects of rice bran phenolic extracts (RBPE) on lipid metabolism. Sixteen-week intake of RBPE (200 mg/kg/d and 400 mg/kg/d) significantly improved the serum lipid profiles of HF diet-fed mice and ameliorated HF diet-induced liver steatosis. Further study showed that RBPE might regulate lipid metabolism through increasing the levels of serum adiponectin, and thereby promoting the activation of 5′ adenosine monophosphate-activated protein kinase α (AMPKα) in liver. Taken together, RBPE might regulate lipid metabolism through adiponectin-mediated AMPK activation and the subsequent reduction of lipid biosynthesis together with the increase of fatty acid oxidation in liver. These results provide us new evidence of the health benefits of rice bran.

米糠是碾米的副产品，其中含有多种营养成分，据报道具有多种活性。在这里，我们使用高脂（HF）饮食诱导的小鼠研究米糠酚类提取物（RBPE）对脂质代谢的影响。摄入16周的RBPE（200 mg / kg / d和400 mg / kg / d）可显着改善HF饮食喂养的小鼠的血脂水平，并改善HF饮食引起的肝脂肪变性。进一步的研究表明，RBPE可能通过增加血清脂联素的水平来调节脂质代谢，从而促进肝脏中5'腺苷单磷酸激活的蛋白激酶α（AMPKα）的激活。在一起 RBPE可能通过脂联素介导的AMPK活化以及随后脂质生物合成的减少以及肝脏中脂肪酸氧化的增加来调节脂质代谢。这些结果为我们提供了米糠对健康有益的新证据。