OBJECTIVE Accumulating evidence has demonstrated a correlation of preoperative controlling nutritional status (CONUT) score with prognosis in several malignancies, but only few studies have explored the influence of preoperative COUNT score in glioblastoma multiforme (GBM). Therefore, this study aimed to validate the connection between the clinical outcome of patients with GBM and the preoperative CONUT score. MATERIALS AND METHODS This study retrospectively evaluated the preoperative CONUT scores of 94 patients with GBM undergoing surgery between December 2015 and May 2018. The cutoff value of the CONUT score was determined using the X-tilesoftware. The influence of preoperative CONUT score on overall survival rate was calculated using the Kaplan-Meier method and Cox proportional hazard regression model. RESULTS The optimal preoperative CONUT score cutoff level was 4, and patients were divided into either low-CONUT score (<4, n = 78, 82.98 %) or high-CONUT score (≥4, n = 16, 17.02 %) groups. After univariate analysis, high-CONUT scores were closely associated with decreased overall survival (hazard ratio [HR]: 2.581, 95 % confidence interval [CI]: 1.475-4.516, p = 0.001). After multivariate analysis, this relationship continued to remain significant (HR: 3.110, 95 % CI: 1.724-5.611, p < 0.001). CONCLUSIONS Current research indicates that the preoperative CONUT score has potential application as a predictor of prognosis in patients with GBM. Thus, it is important that patients with GBM undergo perioperative nutrition interventions according to their CONUT scores, which would be an effective treatment plan to improve their survival and prognosis.

中文翻译：

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术前控制营养状态对胶质母细胞瘤患者的预后价值

目的 越来越多的证据表明，术前控制营养状态 (CONUT) 评分与几种恶性肿瘤的预后相关，但只有少数研究探讨了术前 COUNT 评分对多形性胶质母细胞瘤 (GBM) 的影响。因此，本研究旨在验证 GBM 患者的临床结果与术前 CONUT 评分之间的联系。材料与方法 本研究回顾性评估了 2015 年 12 月至 2018 年 5 月期间接受手术的 94 例 GBM 患者的术前 CONUT 评分。使用 X-tile 软件确定 CONUT 评分的临界值。采用Kaplan-Meier法和Cox比例风险回归模型计算术前CONUT评分对总生存率的影响。结果 最佳术前 CONUT 评分截止水平为 4，患者被分为低 CONUT 评分（<4，n = 78，82.98 %）或高 CONUT 评分（≥4，n = 16，17.02 %）组。单变量分析后，高 CONUT 评分与总体生存率降低密切相关（风险比 [HR]：2.581，95% 置信区间 [CI]：1.475-4.516，p = 0.001）。多变量分析后，这种关系仍然显着（HR：3.110，95% CI：1.724-5.611，p < 0.001）。结论 目前的研究表明，术前 CONUT 评分作为 GBM 患者预后的预测指标具有潜在的应用价值。因此，重要的是 GBM 患者根据其 CONUT 评分进行围手术期营养干预，