There are limited structural brain and retina alteration data from schizophrenia patients who experience visual disturbances (VDs) with or without auditory hallucinations (AHs). We compared brain and retina alterations between first-episode untreated schizophrenia patients with VDs (FUSCH-VDs) with versus without AHs, and between patients and healthy controls (HCs)(N = 30/group). VDs, AHs, gray matter volumes (GMVs), and retinal thicknesses were evaluated with the Bonn Scale for Assessment of Basic Symptoms (BSABS) scale, the Auditory Hallucinations Rating Scale (AHRS), magnetic resonance imaging (MRI), and optical coherence tomography (OCT), respectively. Compared to HCs, FUSCH-VDs had reduced GMVs, mainly in dorsal V3/V3A and V5 regions, the fusiform gyrus, and ventral V4 and V8 regions. Most FUSCH-VDs (85.0%; 51/60) had primary visual cortex-retina co-impairments. FUSCH-VDs with AHs had more serious and larger scope GMV reductions than FUSCH-VDs without AHs. FUSCH-VDs with AHs had significant retinal thickness reductions compared to HCs. Primary visual cortex-retina co-impairments were found to be more common, and more pronounced when present, in FUSCH-VDs with AHs than in FUSCH-VDs without AHs. The present findings support the notion that VDs and AHs may have reciprocal deteriorating actions in patients with schizophrenia.

经历视觉障碍 (VD) 伴或不伴幻听 (AH) 的精神分裂症患者的大脑和视网膜结构改变数据有限。我们比较了首发未经治疗的精神分裂症伴 VDs 患者 (FUSCH-VDs) 与无 AHs 之间以及患者与健康对照者 (HCs) 之间的大脑和视网膜改变 ( N = 30/组）。VD、AH、灰质体积 (GMV) 和视网膜厚度使用波恩基本症状评估量表 (BSABS)、幻听评定量表 (AHRS)、磁共振成像 (MRI) 和光学相干断层扫描进行评估（华侨城），分别。与 HCs 相比，FUSCH-VDs 的 GMVs 减少，主要在背侧 V3/V3A 和 V5 区域、梭状回以及腹侧 V4 和 V8 区域。大多数 FUSCH-VD（85.0%；51/60）有原发性视觉皮层-视网膜共同损伤。与没有 AH 的 FUSCH-VD 相比，具有 AH 的 FUSCH-VD 具有更严重和更大范围的 GMV 减少。与 HC 相比，具有 AH 的 FUSCH-VD 具有显着的视网膜厚度减少。与没有 AH 的 FUSCH-VD 相比，在有 AH 的 FUSCH-VD 中，原发性视觉皮层-视网膜共同损伤被发现更常见，并且当存在时更明显。