Polymers are omnipresent materials that are widely used in medicine, e.g., as construction materials for medical devices or as polymer nanoparticle drug delivery systems. Therefore, their possible effects on biomolecules, such as lipids, proteins, and other molecules, present in the human body must be examined. This review addresses the effects of polymer materials (such as dendrimers, polysaccharides) on the process of amyloid fibril formation. Amyloidoses are very serious diseases that are characterized by amyloid deposition in various organs and tissues, causing their dysfunction. The treatment of amyloidoses, such as Alzheimer’s disease (AD), using polymer materials is a challenge. Studies aiming to elucidate the effects of polymers on the process of amyloid fibril formation are therefore also of key importance for understanding the process of amyloid fibril formation and amyloidoses in general. Graphical abstract Graphical abstract

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聚合物材料作为淀粉样原纤维形成的促进剂/抑制剂

聚合物是广泛用于医学的无所不在的材料，例如，作为医疗器械的构造材料或作为聚合物纳米颗粒药物递送系统。因此，必须检查它们对人体中存在的生物分子（如脂质、蛋白质和其他分子）可能产生的影响。本综述讨论了聚合物材料（如树枝状聚合物、多糖）对淀粉样蛋白原纤维形成过程的影响。淀粉样变性是一种非常严重的疾病，其特征是淀粉样蛋白沉积在各个器官和组织中，导致其功能障碍。使用聚合物材料治疗淀粉样变性，例如阿尔茨海默病 (AD) 是一项挑战。因此，旨在阐明聚合物对淀粉样原纤维形成过程影响的研究对于理解淀粉样原纤维形成过程和一般淀粉样变性也具有关键意义。图形摘要图形摘要