YAP and TAZ are ubiquitously expressed homologous proteins originally identified as penultimate effectors of the Hippo signaling pathway, which plays a key role in maintaining mammalian tissue/organ size. Presently, it is known that YAP/TAZ also interact with various non-Hippo signaling pathways, and have diverse roles in multiple biological processes, including cell proliferation, tissue regeneration, cell lineage fate determination, tumorigenesis, and mechanosensing. In this review, we first examine the various microenvironmental cues and signaling pathways that regulate YAP/TAZ activation, through the Hippo and non-Hippo signaling pathways. This is followed by a brief summary of the interactions of YAP/TAZ with TEAD1-4 and a diverse array of other non-TEAD transcription factors. Finally, we offer a critical perspective on how increasing knowledge of the regulatory mechanisms of YAP/TAZ signaling might open the door to novel therapeutic applications in the interrelated fields of biomaterials, tissue engineering, regenerative medicine and synthetic biology.

YAP和TAZ是普遍表达的同源蛋白，最初被鉴定为Hippo信号通路的倒数第二个效应子，在维持哺乳动物组织/器官大小中起着关键作用。当前，已知YAP / TAZ还与各种非Hippo信号传导途径相互作用，并且在多种生物学过程中具有多种作用，包括细胞增殖，组织再生，细胞谱系命运确定，肿瘤发生和机械传感。在这篇综述中，我们首先研究了通过Hippo和非Hippo信号通路调节YAP / TAZ活化的各种微环境线索和信号通路。接下来是对YAP / TAZ与TEAD1-4和各种其他非TEAD转录因子相互作用的简要概述。最后，