The effect of preventive administration of melatonin on the arrhythmogenic substrate in the myocardium was studied in the rabbit model of acute ischemia/reperfusion in vivo. The animals treated with melatonin 60 min before ischemia induction had shorter median activation time compared to the control group (p=0.039), less pronounced shortening of repolarization durations in the ischemic zone during coronary occlusion (p=0.008), and more complete recovery of repolarization during reperfusion (p=0.027). In the melatonin group, the dispersion of repolarization was less than in the control group during both ischemic period (p=0.043) and reperfusion (p=0.038). Thus, preventive administration of melatonin mitigated the arrhythmogenic substrate in the heart under conditions of ischemia/reperfusion.

中文翻译：

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褪黑激素的预防性给药可减轻心肌缺血的电生理后果

在兔体内急性缺血/再灌注模型中研究了预防性给药褪黑激素对心肌中致心律失常基质的影响。与对照组相比，在缺血诱导前 60 分钟接受褪黑激素治疗的动物的中位激活时间更短（p=0.039），冠状动脉闭塞期间缺血区复极持续时间的缩短不那么明显（p=0.008），以及更完全的恢复再灌注期间的复极（p=0.027）。褪黑激素组在缺血期（p=0.043）和再灌注期（p=0.038）的复极离散度均小于对照组。因此，在缺血/再灌注条件下，褪黑激素的预防性给药减轻了心脏中致心律失常的底物。