We studied the relationship between structural components of the wound (scab, leukocyte shaft, newly formed epithelium, and granulation tissue) and tissue components (epithelial and connective tissue) during spontaneous healing of skin wounds in rats. The regenerate structures were evaluated by microscopic morphometry. The number of vessels in 10 fields of view was calculated (at ×600), the dimensions of newly formed regenerate structures were determined: height of the scab, leukocyte shaft, granulation tissue, the border zone of the epithelium, and the length of the epithelial wedge. For the studied morphometric parameters, regression models of changes in the parameters of the regenerating wound were created depending on the term of the reparative process (days 7 and 14). The correlation analysis of the morphometric parameters of the regenerating wound revealed bilateral strong (direct and inverse) correlations in pairs. Most of the identified dependencies were linear and the changes in the number of vessels in the granulation tissue fit the quadratic regression law. The regularities observed by us during spontaneous healing of full-layer skin defects can be considered as control values for comparison with reparation of similar wounds under conditions of stimulation.

中文翻译：

---

全层皮肤伤口的结构和组织成分与愈合过程的数学模型的关系

我们研究了大鼠皮肤伤口自愈过程中伤口结构成分（痂、白细胞轴、新形成的上皮和肉芽组织）与组织成分（上皮和结缔组织）之间的关系。通过显微形态测定法评估再生结构。计算10个视野中的血管数（×600），确定新形成的再生结构的尺寸：痂的高度、白细胞轴、肉芽组织、上皮的边界带和长度上皮楔形。对于所研究的形态测量参数，根据修复过程的期限（第 7 天和第 14 天）创建了再生伤口参数变化的回归模型。再生伤口的形态测量参数的相关性分析显示双侧强（正反）相关性成对。大多数确定的依赖性是线性的，肉芽组织中血管数量的变化符合二次回归定律。我们在全层皮肤缺损自发愈合过程中观察到的规律可以被认为是与刺激条件下类似伤口修复比较的对照值。