We studied the effects and mechanisms of action of NaHS, an H2S donor, on bovine isolated mesenteric efferent lymphatic vessels pre-contracted with phenylephrine. NaHS induced concentration-dependent relaxation of lymphatic vessels. Removal of the endothelium reduced, but did not completely abolish the relaxing effect of NaHS. Application of NO synthase inhibitor L-NAME, soluble guanylyl cyclase inhibitor ODQ, blocker ATP-sensitive K+ channels glibenclamide, and a combination of blockers of Ca-activated K+ channels of small and intermediate conductance charybdotoxin and apamin attenuated relaxation of lymphatic vessels. Thus, H2S produces a pleiotropic effect on lymphatic vessels; vasorelaxant effect is achieved by several parallel mechanisms. H2S induces relaxation of lymphatic vessels and modulates the rate of lymph transport, thereby affecting the development of immune processes in the body.

中文翻译：

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硫化氢在公牛肠系膜淋巴管扩张中的作用

我们研究了 NaHS（一种 H2S 供体）对用去氧肾上腺素预先收缩的牛分离的肠系膜传出淋巴管的作用和机制。NaHS 诱导淋巴管的浓度依赖性松弛。去除内皮减少，但没有完全消除 NaHS 的松弛作用。应用 NO 合酶抑制剂 L-NAME、可溶性鸟苷酸环化酶抑制剂 ODQ、阻断剂 ATP 敏感 K+ 通道格列本脲，以及 Ca 激活 K+ 通道的小电导和中电导卡里布多毒素和阿巴胺阻滞剂的组合减弱了淋巴管的松弛。因此，H2S 对淋巴管产生多效作用；血管舒张作用是通过几种平行机制实现的。H2S 诱导淋巴管松弛并调节淋巴运输速度，