当前位置: X-MOL 学术Biol. Trace Elem. Res. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Oxidative Stress and Trace Elements in Pulmonary Tuberculosis Patients During 6 Months Anti-tuberculosis Treatment
Biological Trace Element Research ( IF 3.9 ) Pub Date : 2020-06-25 , DOI: 10.1007/s12011-020-02254-0
Chaoqun Qi 1 , Hongjun Wang 2 , Zhaoying Liu 2 , Haibo Yang 2
Affiliation  

Pulmonary tuberculosis (TB) is a well-known cause of imbalance in oxidative stress (OS) status and trace element levels. However, little information is available for targeting the correlation between OS and trace elements in pulmonary TB patients. The aim of our study was to analyze the OS status and its correlation with trace elements in patients initially and during 6 months anti-TB treatment. Eighty-six newly diagnosed pulmonary TB patients were consecutively recruited, and 112 age- and sex-matched healthy controls participated in the study. Serum markers of OS and trace elements levels were tested and analyzed in all subjects during 6 months anti-TB treatment. Compared with healthy controls, significantly increased level of malondialdehyde (MDA), decreased glutathione (GSH) level, superoxide dismutase (SOD), and catalase (CAT) activities were found in TB patients. The activities of SOD and CAT and GSH level recovered till normal range at treatment final. Zinc (Zn), selenium (Se), and copper (Cu) concentrations were significantly lower in TB patients in comparison with healthy controls, whereas Zn, Cu, and Se concentrations rise during 6 months anti-TB treatment. Zn was positively correlated with Cu, Se, and GSH, while MDA was negatively correlated with Zn, Se, SOD, and CAT, and SOD was positively correlated with Cu, Zn, and CAT. Our findings indicate that anti-TB treatment could reduce the status of OS and increase the levels of trace elements. The routine assessment of OS markers and element traces may guarantee improved monitoring the anti-TB treatment.



中文翻译:

6个月抗结核治疗期间肺结核患者的氧化应激和微量元素

肺结核(TB)是氧化应激(OS)状态和微量元素水平不平衡的众所周知原因。然而,很少有信息可用于靶向肺结核患者中OS与微量元素之间的相关性。我们研究的目的是分析患者最初和抗结核治疗6个月期间的OS状况及其与微量元素的相关性。连续招募了86名新诊断的肺结核患者,并有112名年龄和性别相匹配的健康对照参加了研究。在6个月的抗结核治疗期间,对所有受试者的OS血清标志物和微量元素水平进行了测试和分析。与健康对照组相比,丙二醛(MDA)水平明显升高,谷胱甘肽(GSH)水平降低,超氧化物歧化酶(SOD)降低,在结核病患者中发现了过氧化氢酶和过氧化氢酶(CAT)活性。在治疗结束时,SOD,CAT和GSH的活性恢复到正常范围。与健康对照组相比,结核病患者中的锌(Zn),硒(Se)和铜(Cu)浓度显着降低,而抗结核病治疗6个月期间锌,铜和硒的浓度升高。Zn与Cu,Se和GSH正相关,而MDA与Zn,Se,SOD和CAT负相关,SOD与Cu,Zn和CAT正相关。我们的研究结果表明抗结核治疗可以减少OS的状况并增加痕量元素的水平。对OS标志物和元素痕迹的常规评估可确保改善对抗结核治疗的监测。在治疗结束时,SOD,CAT和GSH的活性恢复到正常范围。与健康对照组相比,结核病患者中的锌(Zn),硒(Se)和铜(Cu)浓度显着降低,而抗结核病治疗6个月期间锌,铜和硒的浓度升高。Zn与Cu,Se和GSH正相关,而MDA与Zn,Se,SOD和CAT负相关,SOD与Cu,Zn和CAT正相关。我们的研究结果表明抗结核治疗可以减少OS的状况并增加痕量元素的水平。对OS标志物和元素痕迹的常规评估可确保改善对抗结核治疗的监测。在治疗结束时,SOD,CAT和GSH的活性恢复到正常范围。与健康对照组相比,结核病患者中的锌(Zn),硒(Se)和铜(Cu)浓度显着降低,而抗结核病治疗6个月期间锌,铜和硒的浓度升高。Zn与Cu,Se和GSH正相关,而MDA与Zn,Se,SOD和CAT负相关,SOD与Cu,Zn和CAT正相关。我们的研究结果表明抗结核治疗可以减少OS的状况并增加痕量元素的水平。对OS标志物和元素痕迹的常规评估可确保改善对抗结核治疗的监测。而在抗结核治疗6个月期间,锌,铜和硒的浓度上升。Zn与Cu,Se和GSH正相关,而MDA与Zn,Se,SOD和CAT负相关,SOD与Cu,Zn和CAT正相关。我们的研究结果表明抗结核治疗可以减少OS的状况并增加痕量元素的水平。对OS标志物和元素痕迹的常规评估可确保改善对抗结核治疗的监测。而在抗结核治疗6个月期间,锌,铜和硒的浓度上升。Zn与Cu,Se和GSH正相关,而MDA与Zn,Se,SOD和CAT负相关,SOD与Cu,Zn和CAT正相关。我们的研究结果表明抗结核治疗可以减少OS的状况并增加痕量元素的水平。对OS标志物和元素痕迹的常规评估可确保改善对抗结核治疗的监测。

更新日期:2020-06-25
down
wechat
bug