Anterior urethral reconstruction is still a challenging clinical task, and tissue engineering technology offers new options for anterior urethroplasty. In this work, we evaluated an extracellular matrix (ECM) mimicking scaffold for anterior urethral reconstruction in a New Zealand white rabbit model. After the creation of a urethral defect, the ECM-mimicking scaffold was applied in six rabbits, and small intestinal submucosa (SIS) was used in three rabbits. The outcomes of urethrography and histological analysis were evaluated six months postoperatively. A larger urethral diameter was observed in the ECM-mimicking scaffolds (3.01 ± 0.12 mm) than in the SIS grafts (0.95 ± 0.07 mm). Urethral fistulae and stenosis were observed in the SIS grafts. Urothelial and smooth muscle cells were observed in all rabbits, but the ECM-mimicking scaffold showed better performance. The ECM-mimicking scaffold may be an effective clinical treatment option for congenital and acquired urethral pathol...

中文翻译：

---

一种细胞外基质模拟、双层、异质、多孔、纳米纤维支架，用于兔模型中的前尿道成形术。

前尿道重建仍然是一项具有挑战性的临床任务，组织工程技术为前尿道成形术提供了新的选择。在这项工作中，我们在新西兰白兔模型中评估了用于前尿道重建的细胞外基质 (ECM) 模拟支架。在造成尿道缺损后，6 只兔子使用了 ECM 模拟支架，3 只兔子使用了小肠黏膜下层 (SIS)。术后六个月评估尿道造影和组织学分析的结果。在 ECM 模拟支架 (3.01 ± 0.12 mm) 中观察到比 SIS 移植物 (0.95 ± 0.07 mm) 更大的尿道直径。在SIS移植物中观察到尿道瘘和狭窄。在所有兔子中观察到尿路上皮和平滑肌细胞，但 ECM 模拟支架表现出更好的性能。ECM 模拟支架可能是先天性和获得性尿道病变的有效临床治疗选择...