Strontium (Sr)-doped calcium sulfate hemihydrate (SrCSH) bioactive materials have been demonstrated to promote osteoporotic bone repair, being associated with the stimulation of bone formation and a reduction in bone resorption. However, the rapid degradation and absorption of SrCSH affects its clinical value. In order to delay the degradation time of SrCSH and improve the utilization of Sr 2+ , chitosan (CS)-coated SrCSH microspheres (CS-SrCSH) are prepared by electrostatic interaction between CS and SrCSH. X-ray diffraction analysis verifies that SrCSH coated by CS does not alter the phase composition of the SrCSH. It was observed that CS-SrCSH microspheres have uniform particle size. More importantly, the in vivo and in vitro degradation time of CS-SrCSH microspheres is significantly longer than that of SrCSH, and the release rate of Sr 2+ is stable, achieving a sustained release effect. Furthermore, CS-SrCSH-based cement is used to repair cri...

中文翻译：

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壳聚糖涂层掺锶半水硫酸钙复合水泥的可控降解​​促进骨质疏松大鼠骨缺损修复。

锶 (Sr) 掺杂的半水合硫酸钙 (SrCSH) 生物活性材料已被证明可促进骨质疏松性骨修复，这与刺激骨形成和减少骨吸收有关。然而，SrCSH的快速降解和吸收影响了其临床价值。为了延缓SrCSH的降解时间，提高Sr 2+ 的利用率，利用CS与SrCSH之间的静电相互作用制备了壳聚糖（CS）包覆的SrCSH微球（CS-SrCSH）。X 射线衍射分析证实由 CS 涂覆的 SrCSH 不会改变 SrCSH 的相组成。据观察，CS-SrCSH 微球具有均匀的粒径。更重要的是，CS-SrCSH微球的体内外降解时间明显长于SrCSH，Sr 2+ 的释放速率稳定，达到缓释效果。此外，CS-SrCSH 基水泥用于修复裂缝...