Exposure to environmental pollutants may produce impairment of male reproductive health. The epidemiological literature evaluating potential consequences of human exposure to per- and polyfluoroalkyl substances (PFAS) has grown in recent years with concerns for both pre- and postnatal influences. The aim of this systematic review was to assess available evidence on associations between PFAS exposures in different stages of life and semen quality, reproductive hormones, cryptorchidism, hypospadias, and testicular cancer. A systematic search of literature published prior to March 9th, 2020, was performed in the databases PubMed and Embase®. Predefined criteria for eligibility were applied by two authors screening study records independently. Among the 242 study records retrieved in the literature search, 26 studies were eligible for qualitative assessment. While several investigations suggested weak associations for single compounds and specific outcomes, a lack of consistency across studies limited conclusions of overall evidence. The current gap in knowledge is particularly obvious regarding exposures prior to adulthood, exposure to combinations of both PFAS and other types of environmental chemicals, and outcomes such as cryptorchidism, hypospadias, and testicular cancer. Continued efforts to clarify associations between PFAS exposure and male reproductive health through high-quality epidemiological studies are needed.

暴露于环境污染物可能会损害男性生殖健康。近年来，流行病学文献评估了人类暴露于全氟烷基物质和多氟烷基物质（PFAS）的潜在后果，这引起了人们对产前和产后影响的关注。该系统评价的目的是评估有关不同生命阶段的PFAS暴露与精液质量，生殖激素，隐睾症，尿道下裂和睾丸癌之间的关联的可用证据。在PubMed和Embase®数据库中对2020年3月9日之前发表的文献进行了系统的检索。两位作者分别应用资格预定义的标准筛选研究记录。在文献搜索中检索到的242条研究记录中，有26项研究符合定性评估要求。尽管一些研究表明单一化合物与特定结果之间的关联性较弱，但各研究之间缺乏一致性限制了整体证据的结论。关于成年之前的暴露，PFAS与其他类型的环境化学物的暴露以及隐睾症，尿道下裂和睾丸癌等结局，目前的知识差距尤其明显。需要继续努力，通过高质量的流行病学研究来澄清PFAS暴露与男性生殖健康之间的联系。关于成年之前的暴露，PFAS与其他类型的环境化学物的暴露以及隐睾症，尿道下裂和睾丸癌等结局，目前的知识差距尤其明显。需要继续努力，通过高质量的流行病学研究来阐明PFAS暴露与男性生殖健康之间的联系。关于成年之前的暴露，PFAS与其他类型的环境化学物的暴露以及隐睾症，尿道下裂和睾丸癌等结局，目前的知识差距尤其明显。需要继续努力，通过高质量的流行病学研究来澄清PFAS暴露与男性生殖健康之间的联系。