ABSTRACT

This study was designed to examine the cognitive responses of rat simulation model of the undersea environment. Rats were randomized into five groups: control, restraint, hyperbaric air, restraint with hyperbaric air, and restraint with hyperbaric air and immersion The cognition functions were assessed by Morris water maze test and forced swimming test. The cerebral blood flow (CBF) was monitored. The parameters examined were total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-px), glutathione (GSH), glutathione reductase (GR), and malondialdehyde (MDA). It was observed that the rats in the experimental groups had impaired learning and memory and behavioral despair accompanied by increase in CBF and MDA levels but decrease of TAC, SOD, CAT, GSH-px, GSH, and GR levels. These indicated that the simulated underwater conditions might cause immediate and transient cognition impairment in the rat models. The simulated environment induced oxidative stress led to the negative cognitive changes.

摘要

本研究旨在检验海底环境大鼠模拟模型的认知反应。将大鼠随机分为5组：对照组、克制组、高压空气组、高压空气克制组、高压空气克制组和浸泡组。通过Morris水迷宫试验和强迫游泳试验评估认知功能。监测脑血流量（CBF）。检查的参数是总抗氧化能力 (TAC)、超氧化物歧化酶 (SOD)、过氧化氢酶 (CAT)、谷胱甘肽过氧化物酶 (GSH-px)、谷胱甘肽 (GSH)、谷胱甘肽还原酶 (GR) 和丙二醛 (MDA)。观察到实验组大鼠出现学习记忆障碍和行为绝望，伴有CBF和MDA水平升高，而TAC、SOD、CAT、GSH-px、GSH和GR水平降低。这些表明模拟的水下条件可能会导致大鼠模型中的即时和瞬时认知障碍。模拟环境诱导的氧化应激导致消极的认知变化。